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    When speaking about the most powerful medicines for antifungal therapy, Nizoral is certainly among them. Although it guarantees effective treatment of fungal infections, doctors prescribe it only when there isn’t any other medicine able to help, as Nizoral tablets might cause harm to patient’s liver. Thus, you are to consult your doctor to decide whether it’s worth taking this medicine, and whether there will be more benefits than risks. However, when used externally in the form of cream or shampoo, Nizoral is considered to be both quite effective and safe.

    Mechanism of Action

    Nizoral is a synthetic drug with ketoconazole being an active agent. It also contains such inactive components as colloidal silicon dioxide, magnesium stearate, corn starch, microcrystalline cellulose, povidone and lactose. The active ingredient of Nizoral stops conversion of lanosterol to ergosterol in fungal cellular membranes. Ergosterol can’t be synthesized, which makes the fungal cell vulnerable. It’s performed through ketoconazole inhibiting 14-α demethylase, a cytochrome P-450 enzyme.

    Nizoral is usually prescribed in case of the following systemic diseases:

    bullet_ball_blue Blastomycosis;
    bullet_ball_blue Coccidioidomycosis;
    bullet_ball_blue Candidiasis;
    bullet_ball_blue Histoplasmosis;
    bullet_ball_blue Chromomycosis;
    bullet_ball_blue Paracoccidioidomycosis.

    Physicians fall back upon Nizoral if other kinds of therapy appear to be ineffective.


    Treatment with Nizoral tablets should always be accompanied by laboratory tests to track fungal infection activity. As a rule, the therapy for systemic infections takes 6 months. Adults are recommended to take a single daily dosage of 200 mg, which is one Nizoral tablet. If there isn’t sufficient effect, the dosage should be increased up to a single administration of 400 mg a day. Children starting from the age of 2 can take from 3.3 to 6.6 mg of Nizoral per kilo.

    Ketoconazole needs acid to be absorbed. It’s recommended to take it with food to reduce the risk of upset stomach. Alcohol is strictly prohibited if you keep to Nizoral therapy. Also you mustn’t stop taking the medicine without your doctor’s permission. In case of overdose it’s necessary to seek medical attention.

    Contraindications and Side Effects

    You must tell you doctor about any medicines you are currently taking, as there is a lengthy list of drugs which can result in bad side effects when co-administrated with Nizoral, including CYP3A4 substrates, acidic beverages, antivirals, antibacterials, anticonvulsants, analgesics, etc. These medicines affect ketoconazole plasma concentration by either decreasing or reducing it to abnormal levels. It either makes Nizoral dangerous for your health or absolutely ineffective.

    Apart from other medicines, there are other conditions when Nizoral is contraindicated, such as:

    bullet_ball_blue Allergy to any component of the medicine;
    bullet_ball_blue Hypersensitivity;
    bullet_ball_blue Liver diseases;
    bullet_ball_blue Adrenal gland problems;
    bullet_ball_blue QT syndrome;
    bullet_ball_blue Pregnancy;
    bullet_ball_blue Breastfeeding.

    Nizoral can cause the following minor side effects:

    bullet_ball_blue Headache;
    bullet_ball_blue Itching;
    bullet_ball_blue Dizziness;
    bullet_ball_blue Nausea;
    bullet_ball_blue Vomiting;
    bullet_ball_blue Stomach pain;
    bullet_ball_blue Breast swelling;
    bullet_ball_blue Impotence.

    In case you experience severe side effects, including vision changes, mental changes, bleeding, fainting or fast heartbeat, you are to call your doctor at once.


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