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    Methotrexate contains an innovative formula, which interferes with the development and expansion of certain body cells. The treatment influences mainly the cells that feature fast reproduction, especially skin cells, bone marrow cells, cancer cells and others. Thus, Methotrexate is commonly prescribed as a remedy against diverse types of head and neck, lung, breast and skin cancer. Moreover, it can also be taken to improve the symptoms of rheumatoid arthritis and psoriasis. Due to the drastic impact the medication produces on the organism, it is commonly used if similar medications failed to cause positive changes. Contact your healthcare specialist before you use the drug, especially off-label.

    Safety Considerations before the Medication Intake: Precautions, Contraindications and Warnings

    Never start Methotrexate intake without doctor’s prescription. Otherwise, you risk experiencing significant condition aggravations or other abnormalities. Methotrexate is contraindicated for patients, allergic to its composition. Additionally, the remedy should not be administered by people, who have underlying or accompanying health disorders, especially:

    bullet_ball_blue Bone marrow disorder;
    bullet_ball_blue Alcohol or drug addiction;
    bullet_ball_blue Cirrhosis;
    bullet_ball_blue Kidney or liver impairments;
    bullet_ball_blue Pregnancy or lactation and others.

    Additionally, to ensure a 100% safe treatment course, a patient should inform a physician about illnesses and complications he/she has with exceptional regard to:

    bullet_ball_blue Pneumonia and other lung disorders;
    bullet_ball_blue Foliate deficiency;
    bullet_ball_blue Kidney complications;
    bullet_ball_blue Infectious disorders;
    bullet_ball_blue Stomach ulcers and others.

    Recommendations for Safe Treatment Course and Optimal Doses

    When taking Methotrexate, following the prescription and safety guide is inevitable. It is important to take the drug in accordance with the instructions and directions of your healthcare specialist. Never change the dose, duration of the therapy or other adjustments to eliminate possible complications. The treatment should be taken regularly, but not always daily. The frequency of Methotrexate intake will depend on the severity of the complication and overall health state. The average dose, sufficient for a positive effect, is 3.3 mg/m2/day.

    Methotrexate and Other Drugs: Interactions and Possible Side Effects

    Provide your healthcare specialist with details of other therapies you have. Certain prescription and generic drugs and other pharmaceutical products may interact with Methotrexate, causing aggravating complications. Warn your doctor about:

    bullet_ball_blue NSAIDs;
    bullet_ball_blue Antibiotics;
    bullet_ball_blue Salicylates;
    bullet_ball_blue Probenecid;
    bullet_ball_blue Phenytoin;
    bullet_ball_blue Azathioprine;
    bullet_ball_blue Theophylline;
    bullet_ball_blue Leucovorin and other medications you use.

    Seek emergency medical assistance if such combinations have led to allergic reactions or other severe side effects, including:

    bullet_ball_blue Vision disorders;
    bullet_ball_blue Breathing problems;
    bullet_ball_blue Convulsions;
    bullet_ball_blue Bloody or watery urine;
    bullet_ball_blue Swelling;
    bullet_ball_blue Diarrhea, nausea, vomiting and others.