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    Endep is an oral medication that belongs to a group of drugs called TCAs, or tricyclic antidepressants. It’s often used to treat depression, and it was approved by the FDA in 1983. This medicine is often prescribed by doctors to help their patients elevate mood if they suffer from depression. Besides, Endep can be used to treat such health conditions as ADHD, eating disorders, migraines and some others. It’s believed that people with depression have certain imbalances in neurotransmitters.

    Just like other effective TCAs, Endep works by increasing the levels of serotonin and norepinephrine in the brain while blocking the action of acetylcholine, thus, elevating the mood of patients. This medicine is available as tablets that come in a range of doses, from 10 mg to 150 mg for added convenience. You can take it both with and without food, either in divided doses or right before your bedtime, and a standard adult dose is 100-300 mg taken on a daily basis. The initial Endep dose of most patients is 50-100 mg that can be increased gradually.

    Possible Mild and Serious Adverse Effects and Important Warnings

    All medications result in specific side effects, and Endep is no exception. So people who take it may end up with the following mild symptoms:

    bullet_ball_blue Blurred vision and dry mouth;
    bullet_ball_blue Fast heartbeat and constipation;
    bullet_ball_blue Urinary retention and low blood pressure;
    bullet_ball_blue Sexual dysfunction and allergic reactions;
    bullet_ball_blue Unexplained weight loss or gain.

    There are less common side effects that can be caused by the intake of Endep, too, including:

    bullet_ball_blue Hives and skin rash;
    bullet_ball_blue Hepatitis and seizures.

    This medicine should be used with enough caution by patients who have seizures, because it may increase their risk of having this condition. Besides, people who have glaucoma risk ending up with increased pressure in their eyes, while users with prostate enlargement should be careful because of the risk of their increased inability to urinate.

    If the use of this medication is stopped abruptly, you risk ending up with such unwanted symptoms as unusual restlessness, nausea, dizziness and headaches. These withdrawal symptoms may appear even if you miss a few doses, so it’s necessary to reduce daily doses gradually to discontinue this therapy.

    All antidepressants increase the risk of having suicidal thoughts and behaviors, especially in adolescents and children with depression and different psychiatric disorders. If you consider the intake of Endep, you should discuss possible risks and benefits with qualified doctors. They must closely observe you for any clinical worsening, unusual behavioral changes and suicidal thinking.

    In addition, you shouldn’t combine Endep with specific medications to avoid dangerous drug interactions. If you take it together with any MAO inhibitor, you risk ending up with such symptoms as convulsions and high fever. Don’t take this antidepressant with epinephrine, cimetidine and alcoholic beverages.


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